Cefuroxime concentrations in facial artery musculomucosal flap, buccal submucosa, subcutaneous tissue, and plasma following bolus or continuous infusion in patients undergoing oral cancer resection: a randomized clinical microdialysis study

A daily dose of 4500 mg cefuroxime provides adequate tissue and plasma concentrations with both BI and CI to achieve ≥50%T > MIC in patients undergoing oral cavity cancer surgery with FAMM flap reconstruction. CI provided more consistent exposure and may offer pharmacokinetic advantages in selected high-risk situations/patients.

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Publication Details

Journal
Journal of Antimicrobial Chemotherapy
Published
2026-02-24
DOI
https://doi.org/10.1093/jac/dkag085
Primary Topic
Oral health in cancer treatment
Type
article
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article

Cefuroxime concentrations in facial artery musculomucosal flap, buccal submucosa, subcutaneous tissue, and plasma following bolus or continuous infusion in patients undergoing oral cancer resection: a randomized clinical microdialysis study

Pelle Hanberg, Eva Greibe, Jennifer K. Hansen, Arunas Pikelis et al.
Journal of Antimicrobial Chemotherapy
Oral health in cancer treatment
article

Cefuroxime concentrations in facial artery musculomucosal flap, buccal submucosa, subcutaneous tissue, and plasma following bolus or continuous infusion in patients undergoing oral cancer resection: a randomized clinical microdialysis study

Pelle Hanberg, Eva Greibe, Jennifer K. Hansen, Arunas Pikelis, S. Hillerup, Søren Dürr Gade, Tejs Ehlers Klug
article en

Abstract

A daily dose of 4500 mg cefuroxime provides adequate tissue and plasma concentrations with both BI and CI to achieve ≥50%T > MIC in patients undergoing oral cavity cancer surgery with FAMM flap reconstruction. CI provided more consistent exposure and may offer pharmacokinetic advantages in selected high-risk situations/patients.

Journal of Antimicrobial ChemotherapyVol. 81(4)
Aarhus University (DK), Aarhus University Hospital (DK)
Good health and well-being
Openalex Percentile: Top 30%
Oral health in cancer treatment
DOISourceOpenAlex
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Cefuroxime concentrations in facial artery musculomucosal flap, buccal submucosa, subcutaneous tissue, and plasma following bolus or continuous infusion in patients undergoing oral cancer resection: a randomized clinical microdialysis study — Pelle Hanberg, Eva Greibe, et al. · Journal of Antimicrobial Chemotherapy (2026) | TGRS Research Map | TGRS