Lemmel Syndrome Causing Obstructive Jaundice: A Rare Presentation of Periampullary Duodenal Diverticulum Managed by Surgical Decompression – A Case Report

Background: Lemmel syndrome is a rare cause of obstructive jaundice resulting from extrinsic compression of the common bile duct (CBD) by a periampullary duodenal diverticulum. It occurs in the absence of choledocholithiasis or malignancy and is frequently overlooked due to its nonspecific clinical presentation. Case Presentation: A 74-year-old male presented with progressive jaundice, intermittent fever, pruritus, dyspepsia, and upper abdominal discomfort for one month. Initial investigations demonstrated biliary dilatation without evidence of choledocholithiasis. Contrast-enhanced computed tomography (CECT) and endoscopic retrograde cholangiopancreatography (ERCP) demonstrated a large periampullary duodenal diverticulum compressing the distal CBD, consistent with Lemmel syndrome. Despite endoscopic therapy and medical management, the patient developed persistent cholangitis and worsening jaundice. Surgical exploration was performed, and cholecystectomy with choledochotomy, CBD stent insertion, and peritoneal toileting were carried out. No gallstones or CBD stones were identified intraoperatively. The postoperative course was uneventful, with progressive normalization of liver function tests and resolution of jaundice. Conclusion: Lemmel syndrome is an uncommon but important differential diagnosis in elderly patients with obstructive jaundice. Awareness of this entity and appropriate imaging are essential for early diagnosis. Endoscopic therapy is the preferred initial approach, but surgical intervention provides effective treatment when endoscopic management fails.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-03-07
DOI
https://doi.org/10.5281/zenodo.18899183
Primary Topic
Gallbladder and Bile Duct Disorders
Type
article
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article

Lemmel Syndrome Causing Obstructive Jaundice: A Rare Presentation of Periampullary Duodenal Diverticulum Managed by Surgical Decompression – A Case Report

Aung Ko Ko Linn, Khin Aung Htun, Soe Htut Aung, Min Nay Zar Wyke et al.
Zenodo (CERN European Organization for Nuclear Research)
Gallbladder and Bile Duct Disorders
article

Lemmel Syndrome Causing Obstructive Jaundice: A Rare Presentation of Periampullary Duodenal Diverticulum Managed by Surgical Decompression – A Case Report

Aung Ko Ko Linn, Khin Aung Htun, Soe Htut Aung, Min Nay Zar Wyke, Thant Lwyn San, Min Htet San, Kyaw Thu Linn
article en

Abstract

Background: Lemmel syndrome is a rare cause of obstructive jaundice resulting from extrinsic compression of the common bile duct (CBD) by a periampullary duodenal diverticulum. It occurs in the absence of choledocholithiasis or malignancy and is frequently overlooked due to its nonspecific clinical presentation. Case Presentation: A 74-year-old male presented with progressive jaundice, intermittent fever, pruritus, dyspepsia, and upper abdominal discomfort for one month. Initial investigations demonstrated biliary dilatation without evidence of choledocholithiasis. Contrast-enhanced computed tomography (CECT) and endoscopic retrograde cholangiopancreatography (ERCP) demonstrated a large periampullary duodenal diverticulum compressing the distal CBD, consistent with Lemmel syndrome. Despite endoscopic therapy and medical management, the patient developed persistent cholangitis and worsening jaundice. Surgical exploration was performed, and cholecystectomy with choledochotomy, CBD stent insertion, and peritoneal toileting were carried out. No gallstones or CBD stones were identified intraoperatively. The postoperative course was uneventful, with progressive normalization of liver function tests and resolution of jaundice. Conclusion: Lemmel syndrome is an uncommon but important differential diagnosis in elderly patients with obstructive jaundice. Awareness of this entity and appropriate imaging are essential for early diagnosis. Endoscopic therapy is the preferred initial approach, but surgical intervention provides effective treatment when endoscopic management fails.

Zenodo (CERN European Organization for Nuclear Research)
Military Hospital (PK), Myanmar Oxford Clinical Research Unit (MM), Livestock Breeding and Veterinary Department (MM)
Good health and well-being
Openalex Percentile: Top 30%
Gallbladder and Bile Duct Disorders
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Lemmel Syndrome Causing Obstructive Jaundice: A Rare Presentation of Periampullary Duodenal Diverticulum Managed by Surgical Decompression – A Case Report — Aung Ko Ko Linn, Khin Aung Htun, et al. · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS