Comparative effectiveness of CDK4/6 inhibitors in metastatic breast cancer: using the target trial emulation framework to investigate overall survival in routine care

Using target trial emulation, real-world OS is similar with palbociclib/ribociclib/abemaciclib plus AI. These findings may contribute to the development of combination strategies to improve clinical outcomes and to guide clinical decision-making.

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Publication Details

Journal
Breast Cancer Research and Treatment
Published
2026-03-07
DOI
https://doi.org/10.1007/s10549-026-07935-3
Primary Topic
Advanced Breast Cancer Therapies
Type
article
Field-Weighted Citation Impact
0.00

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article

Comparative effectiveness of CDK4/6 inhibitors in metastatic breast cancer: using the target trial emulation framework to investigate overall survival in routine care

Jessica Davies, A Brufsky, Otto Metzger, A A Grigorenko et al.
Breast Cancer Research and Treatment
Advanced Breast Cancer Therapies
article

Comparative effectiveness of CDK4/6 inhibitors in metastatic breast cancer: using the target trial emulation framework to investigate overall survival in routine care

Jessica Davies, A Brufsky, Otto Metzger, A A Grigorenko, Gráinne H. Long, Sameet Sreenivasan, Rodrigo Goncalves, Ula Nur, Richard S. Finn, Cynthia Huang-Bartlett
article en

Abstract

Using target trial emulation, real-world OS is similar with palbociclib/ribociclib/abemaciclib plus AI. These findings may contribute to the development of combination strategies to improve clinical outcomes and to guide clinical decision-making.

Breast Cancer Research and TreatmentVol. 216(2)
University of California, Los Angeles (US), AstraZeneca (Australia) (AU), AstraZeneca (Netherlands) (NL), AstraZeneca (Singapore) (SG), University of Pittsburgh Medical Center (US), AstraZeneca (Spain) (ES), Dana-Farber Brigham Cancer Center (US)
AstraZeneca
Good health and well-being
Openalex Percentile: Top 30%
Advanced Breast Cancer Therapies
DOIOpen Access PDFOpenAlex
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Comparative effectiveness of CDK4/6 inhibitors in metastatic breast cancer: using the target trial emulation framework to investigate overall survival in routine care — Jessica Davies, A Brufsky, et al. · Breast Cancer Research and Treatment (2026) | TGRS Research Map | TGRS