Dusp15 modulates mtHsp70 Thr116 phosphorylation state to preserve mito-UPR and attenuate cardiac dysfunction in diabetic cardiomyopathy
Dusp15 is a stress-responsive regulator that protects against diabetic cardiac dysfunction and remodeling through mtHsp70-associated mito-UPR signaling. Targeting the Dusp15-mtHsp70 axis may represent a therapeutic strategy for diabetic cardiomyopathy.
Authors
- Hongshuo Shi (ORCID: https://orcid.org/0000-0003-0012-5869)
- Xiuling He
- Haowen Zhuang
- Yuanyuan Wang
- Ying Jiang
- Yinglong Li
- Zhiyu Jin
- Zhijiang Guo
- Sangbing Ong
- Yan Liu
- Xing Chang
- Chun Li
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Shandong University of Traditional Chinese Medicine (CN)
- Chinese University of Hong Kong (HK)
- Guangdong Pharmaceutical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Guang’anmen Hospital (CN)
- Shuguang Hospital (CN)
- Qilu Hospital of Shandong University (CN)
- Dali University (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2026-03-07
- DOI
- https://doi.org/10.1186/s12933-026-03125-z
- Primary Topic
- Heat shock proteins research
- Type
- article
- Field-Weighted Citation Impact
- 0.00