Prevalence and mortality of cardiovascular-kidney-metabolic syndrome in US adults, 1999–2018
Nearly 90% of US adults have Stage 1 or higher CKM syndrome, and CKM stage is associated with graded mortality risk. Metabolic abnormalities explain the largest share of the mortality gradient, suggesting that population and clinical strategies focused on metabolic risk reduction should be prioritized to reduce CKM-related mortality.
Authors
- Sourbha S. Dani (ORCID: https://orcid.org/0000-0002-3434-6136)
- Anandita Kulkarni
- Huzaifa Ahmad Cheema (ORCID: https://orcid.org/0000-0001-6783-7137)
- Saad Ur Rahman (ORCID: https://orcid.org/0000-0002-4838-0802)
- Abia Shahid
- Sarju Ganatra
- Janani Rangaswami
- Jaideep Patel
- Khurram Nasir
Institutions
- Houston Methodist (US)
- King Edward Medical University (PK)
- George Washington University (US)
- Lahey Medical Center (US)
- Heart Hospital Baylor Plano (US)
- Johns Hopkins Hospital (US)
- Washington DC VA Medical Center (US)
Publication Details
- Journal
- American Heart Journal Plus Cardiology Research and Practice
- Published
- 2026-03-07
- DOI
- https://doi.org/10.1016/j.ahjo.2026.100742
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00