Endothelial ADGRF5(GPR116) governs vascular adaptation required for sustained thermogenic remodeling of brown adipose tissue
Endothelial ADGRF5(GPR116) is a critical regulator of vascular adaptation during sustained cold exposure and supports full acquisition of the thermogenic adipocyte state through endothelial identity and paracrine signaling.
Authors
- Anastasia Georgiadi (ORCID: https://orcid.org/0000-0002-9648-8682)
- Dagmar Wachten (ORCID: https://orcid.org/0000-0003-4800-6332)
- Ankush Kumar Jha (ORCID: https://orcid.org/0000-0001-7594-6886)
- Ronja Kardinal (ORCID: https://orcid.org/0009-0004-3649-2024)
- Lea Seep
- Jörg Heeren
- Vasiliki Karagiannakou
- Rabih El-Merahbi
- Stephan Grein
- Alexander Pfeifer
- Stephan Herzig
- Aspasia Thodou Krokidi
- Mersiha Hasic
- Martin Klingenspor
- Felix Meissner
- Richard Lindner
- Kenneth Dyar
- Jan Hasenauer
- Michelle Ynonne Jäckstein
Institutions
- University of Bonn (DE)
- Universität Hamburg (DE)
- Heidelberg University (DE)
- University Hospital Bonn (DE)
- University Hospital Heidelberg (DE)
- Center for Environmental Health (US)
- Helmholtz Zentrum München (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Deutsches Diabetes-Zentrum e.V. (DE)
- German Center for Diabetes Research (DE)
- Heinrich Heine University Düsseldorf (DE)
- Technical University of Munich (DE)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2026-03-07
- DOI
- https://doi.org/10.1016/j.molmet.2026.102346
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00