Superenhancer-mediated ferroptosis in age-related hearing loss: cochlear epigenomics
This study provides evidence for the role of Sp1 and Fth1 in the regulation of HC aging and ARHL. These findings suggest that manipulating SE sites and inhibiting ferroptosis may offer novel therapeutic strategies for treating ARHL. Understanding the interplay between SEs, Sp1, Fth1 and ferroptosis reveals novel targets for AAV gene therapy to preserve hearing in aging populations by modulating iron homeostasis during sensory cell senescence.
Authors
- Xiaoqin Luo (ORCID: https://orcid.org/0009-0002-3907-1087)
- Ting Yang
- Xiaolong Fu
- Wei Yuan
- Chanyuan Zhang
- Yan Sun
Institutions
- Qingdao University (CN)
- Chongqing University (CN)
- Southwest Medical University (CN)
- Yuhuangding Hospital (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- Chongqing Emergency Medical Center (CN)
- First People's Hospital of Chongqing (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2026-03-07
- DOI
- https://doi.org/10.1007/s00018-026-06117-0
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- Centre Scientifique et Technique du Bâtiment