Dental pulp stem cells maintain epigenetic chromatin architecture remodeling primed by the etiological stimulus of biliary atresia
The present epigenetic memory in BA-SHED implies that BA-SHED imprint bile duct deficiency through TGFBR2 dysregulated by the HNF6 promoter activation epigenetically. Thus, BA-SHED are a potential model for expanding our knowledge in BA research.
Authors
- Haruyoshi Yamaza (ORCID: https://orcid.org/0000-0003-1138-3943)
- Koichiro Yoshimaru (ORCID: https://orcid.org/0000-0002-8709-7313)
- Tatsuro Tajiri (ORCID: https://orcid.org/0009-0006-6314-2024)
- Sara Murata
- Soichiro Sonoda (ORCID: https://orcid.org/0000-0001-8464-0061)
- Ratih Yuniartha (ORCID: https://orcid.org/0000-0002-9619-1010)
- Yamaza Takayoshi
- Mohammed Fouad Zakaria
- Ying Liu
- Tomoaki Taguchi
- Liting Yu
- M. Majd Sharifa
- Toshiharu Matsuura
- Satoshi Fukumoto
- Hiroki Kato
- Lisha Dai
Institutions
- Kagoshima University (JP)
- Kyushu University (JP)
- Universitas Gadjah Mada (ID)
- Kyushu Dental University (JP)
- Fukuoka College of Health Sciences (JP)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2026-03-07
- DOI
- https://doi.org/10.1186/s13287-026-04952-3
- Primary Topic
- Pediatric Hepatobiliary Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00