Automated cassette-based synthesis, metabolism, and dosimetry of [18F]ApaScan, a PET tracer for aldosterone synthase imaging
[<sup>18</sup>F]ApaScan undergoes oxidative metabolism while maintaining favorable adrenal kinetics and exhibiting acceptable dosimetry. We established a reproducible automated radiosynthesis of [<sup>18</sup>F]ApaScan suitable for clinical use. These findings support proceeding to first-in-human studies to evaluate the pharmacokinetics and APA imaging performance of [<sup>18</sup>F]ApaScan in patients with PA.
Authors
- Fumitoshi Satoh (ORCID: https://orcid.org/0000-0003-0720-0470)
- Ryuichi Harada (ORCID: https://orcid.org/0000-0001-8538-8814)
- Yuta Tezuka (ORCID: https://orcid.org/0000-0003-1546-6949)
- Shozo Furumoto (ORCID: https://orcid.org/0000-0002-9296-3079)
- Hideki Katagiri (ORCID: https://orcid.org/0000-0002-2786-8569)
- Kei Takase (ORCID: https://orcid.org/0000-0003-0931-9942)
- Miho Shidahara
- Toko Otaka
- Yuki Shimizu
- Takayuki Sakai
- Tomohiro Kaneta
- Ren Iwata
- Yuta Tezuka
- Takashi Suzuki
- Hironobu Sasano
Institutions
- Tohoku University (JP)
- Tohoku University Hospital (JP)
- Tohoku Medical and Pharmaceutical University (JP)
Publication Details
- Journal
- Nuclear Medicine and Biology
- Published
- 2026-03-07
- DOI
- https://doi.org/10.1016/j.nucmedbio.2026.109621
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 0.00