Generation of a human induced pluripotent stem cell line (FLENIi004-A) from an Autosomal-Dominant Alzheimer’s disease PSEN1 p.M146L patient
Human induced pluripotent stem cell (hiPSC) line FLENIi004-A was generated from peripheral blood mononuclear cells (PBMCs) using the lentiviral-hSTEMCCA-loxP vector. FLENIi004-A was derived from a 41-year-old Argentinean Caucasian male patient with Autosomal-Dominant Alzheimer's Disease, who carried the heterozygous PSEN1 p.M146L mutation. The hiPSC line retained the PSEN1 mutation, and its pluripotency and trilineage differentiation potential were confirmed.
Authors
- Ezequiel Surace (ORCID: https://orcid.org/0000-0001-8492-9578)
- Micaela Nievas (ORCID: https://orcid.org/0009-0007-4588-7468)
- Leonardo Romorini (ORCID: https://orcid.org/0000-0002-3972-0991)
- Gustavo Sevlever (ORCID: https://orcid.org/0000-0002-9567-7553)
- Mariela C. Marazita (ORCID: https://orcid.org/0000-0002-6944-2486)
- María S. Rodriguez Varela
- María Élida Scassa (ORCID: https://orcid.org/0000-0002-2158-5306)
- M. Vautier
- Manuela Apecetche
- Victoria Massazza
- Giulia Clas
- Guillermo Jerez Ferreyra
- Patricio Chrem Mendez
- Ricardo Allegri
Institutions
- Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (AR)
Publication Details
- Journal
- Stem Cell Research
- Published
- 2026-03-07
- DOI
- https://doi.org/10.1016/j.scr.2026.103958
- Primary Topic
- Pluripotent Stem Cells Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00