Is it “Time to Eliminate” Time to Elimination of Symptoms as a Primary Trial End Point for Drugs Targeting Respiratory Viruses?
Time to symptom elimination is a statistically inefficient end point for respiratory virus trials that ignores the most clinically relevant time points. Alternatively, clearance slope and area under the curve may efficiently capture improvement early during treatment when symptoms are most severe.
Authors
- Katherine Owens (ORCID: https://orcid.org/0000-0002-5695-0203)
- Michael Boeckh
- Joshua T Schiffer
- Alpana Waghmare
- Shadisadat Esmaeili
Institutions
- University of Washington (US)
- Fred Hutch Cancer Center (US)
- Seattle Children's Hospital (US)
- Seattle Institute for Biomedical and Clinical Research (US)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1093/infdis/jiag148
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00