Molecular biology of radiation response and resistance

Biology-guided stratification could personalise radiotherapy indication, dose/fractionation and systemic partnering in HNSCC. Prospective validation of clinical assays and trial designs capturing dynamic resistance are now key priorities.

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Publication Details

Journal
Current Opinion in Oncology
Published
2026-01-29
DOI
https://doi.org/10.1097/cco.0000000000001213
Primary Topic
Effects of Radiation Exposure
Type
article
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article

Molecular biology of radiation response and resistance

Amy Young, Ben O’Leary
Current Opinion in Oncology
Effects of Radiation Exposure
article

Molecular biology of radiation response and resistance

Amy Young, Ben O’Leary
article en

Abstract

Biology-guided stratification could personalise radiotherapy indication, dose/fractionation and systemic partnering in HNSCC. Prospective validation of clinical assays and trial designs capturing dynamic resistance are now key priorities.

Current Opinion in Oncology
Institute of Cancer Research (GB), Royal Marsden Hospital (GB)
Openalex Percentile: Top 32%
Effects of Radiation Exposure
DOISourceOpenAlex
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Molecular biology of radiation response and resistance — Amy Young, Ben O’Leary · Current Opinion in Oncology (2026) | TGRS Research Map | TGRS