Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning

RNA language models (LMs) are increasingly applied to RNA structure and function analysis, yet their intrinsic representational capacities remain poorly characterized. Here, we present a standardized zero-shot evaluation of 21 RNA LMs, with representative DNA LMs included as reference controls. Three complementary tasks-attention-based RNA secondary structure prediction, embedding-based RNA classification, and mutational fitness estimation from sequence likelihoods-are evaluated without downstream fine-tuning. Our results reveal substantial variability across models and clear trade-offs between structural, functional, and evolutionary representations. RNA-specific, noncoding RNA-enriched pretraining is crucial for capturing structural information, while evolutionary signals from multiple sequence alignments substantially boost performance. Although model scaling yields gains, architectural and objective choices critically influence performance across task categories. Together, this study provides a foundational benchmark, highlights inherent challenges in learning unified RNA representations, and offers insights for developing next-generation RNA foundation models.

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Publication Details

Journal
Briefings in Bioinformatics
Published
2026-02-12
DOI
https://doi.org/10.1093/bib/bbag098
Primary Topic
RNA and protein synthesis mechanisms
Type
article
Field-Weighted Citation Impact
0.00

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article

Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning

Jian Zhan, Yaoqi Zhou, Yikun Zhang, Jie Chen et al.
Briefings in Bioinformatics
RNA and protein synthesis mechanisms
article

Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning

Jian Zhan, Yaoqi Zhou, Yikun Zhang, Jie Chen, He Wang
article en

Abstract

RNA language models (LMs) are increasingly applied to RNA structure and function analysis, yet their intrinsic representational capacities remain poorly characterized. Here, we present a standardized zero-shot evaluation of 21 RNA LMs, with representative DNA LMs included as reference controls. Three complementary tasks-attention-based RNA secondary structure prediction, embedding-based RNA classification, and mutational fitness estimation from sequence likelihoods-are evaluated without downstream fine-tuning. Our results reveal substantial variability across models and clear trade-offs between structural, functional, and evolutionary representations. RNA-specific, noncoding RNA-enriched pretraining is crucial for capturing structural information, while evolutionary signals from multiple sequence alignments substantially boost performance. Although model scaling yields gains, architectural and objective choices critically influence performance across task categories. Together, this study provides a foundational benchmark, highlights inherent challenges in learning unified RNA representations, and offers insights for developing next-generation RNA foundation models.

Briefings in BioinformaticsVol. 27(2)
BGI Group (China) (CN), Lishui University (CN), Shenzhen Bay Laboratory (CN), Tang Hospital (CN)
National Natural Science Foundation of China
Openalex Percentile: Top 31%
RNA and protein synthesis mechanisms
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