Flow-induced Klf4-Akt signaling links EC cycling to mural cell defects in arterial-venous malformations
Our study establishes EC cycle state as the upstream determinant of mural cell stability under pathological flow and provides the mechanistic reasoning for why distinct therapeutic strategies (e.g., CDK4/6 inhibition, Akt modulation, or thalidomide-induced PDGFB upregulation) converge on AVM stabilization.
Authors
- Roxana Ola (ORCID: https://orcid.org/0000-0002-2566-4431)
- Yanzhu Lin (ORCID: https://orcid.org/0000-0002-4547-1493)
- Kuheli Banerjee (ORCID: https://orcid.org/0000-0003-4381-2028)
- Johannes Gahn (ORCID: https://orcid.org/0000-0002-9066-0664)
- Fan Wu (ORCID: https://orcid.org/0000-0001-7036-7674)
- Caroline Theresa Seebauer (ORCID: https://orcid.org/0009-0002-2258-5604)
- Yuxi Di
- Zohrah Hashemi
- Tanmaya Behera
- Qing Zhang
- Kornelia Andorfer
- Mahak Singhal
Institutions
- Sun Yat-sen University (CN)
- Max Delbrück Center (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Luzerner Kantonsspital (CH)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Theranostics
- Published
- 2026-02-26
- DOI
- https://doi.org/10.7150/thno.121154
- Primary Topic
- Vascular Malformations and Hemangiomas
- Type
- article
- Field-Weighted Citation Impact
- 0.00