Globo H ceramide confers chemoresistance and poor prognosis to advanced gallbladder cancer via A2AR/cAMP/PKA pathway
GHCer promotes GR by upregulating ABCG2 via A2AR/cAMP/PKA signaling. Targeting Globo H may improve chemotherapy response in GBC.
Authors
- Wu CE
- Jung‐Tung Hung (ORCID: https://orcid.org/0000-0001-7161-1915)
- Alice L. Yu (ORCID: https://orcid.org/0000-0003-2444-0505)
- Yenlin Huang
- Jing-Yan Cheng
- Chun-Nan Yeh
- Chien-Wei Lee
- Yi-Chia Wu
- Wen-Kuan Huang
- Tsai-Hsien Hung
- John Yu
Institutions
- Kaohsiung Medical University (TW)
- Chang Gung University (TW)
- National Tsing Hua University (TW)
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
- Chang Gung Memorial Hospital (TW)
- University of California San Diego (US)
- Linkou Chang Gung Memorial Hospital (TW)
Publication Details
- Journal
- Theranostics
- Published
- 2026-02-26
- DOI
- https://doi.org/10.7150/thno.126092
- Primary Topic
- Protein Kinase Regulation and GTPase Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chang Gung Memorial Hospital
- Chang Gung Medical Foundation
- National Science and Technology Council