Molecular hydrogen triggers TRPC4-TRPC4AP-dependent reversible calcium transients via extracellular influx
This study identifies H<sub>2</sub> as a novel gaseous signaling molecule that can regulate Ca<sup>2+</sup> channels via the TRPC4-TRPC4AP axis. The 730Arg-731Arg motif in TRPC4 serves as a critical H<sub>2</sub>-sensitive site, enabling dynamic calcium homeostasis without overload. These findings provide a mechanistic framework for developing gas-controlled H<sub>2</sub> regenerative therapeutics.
Authors
- Xujuan Zhang (ORCID: https://orcid.org/0000-0001-5061-0913)
- Zheng Dang
- Jiateng Wang
- Xiaohu Wen
- Fei Xie (ORCID: https://orcid.org/0000-0003-3674-8216)
- Han Li (ORCID: https://orcid.org/0000-0002-0286-3737)
- Zisong Cai
- Shihao Jiang
- Ziyi Liu
- Xuemei Ma
- Xue Jiang
- Pengxiang Zhao
- Mengyu Liu
Institutions
- Beijing University of Technology (CN)
Publication Details
- Journal
- Theranostics
- Published
- 2026-02-26
- DOI
- https://doi.org/10.7150/thno.124352
- Primary Topic
- Ion Channels and Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00