Design and Synthesis of Piperidine Hydroxamate Scaffolds as Novel HDAC Inhibitors with Apoptotic Potential in Human Cervical Cancer Cells
The findings of this research underscore the therapeutic potential of piperidine hydroxamate scaffolds, specifically compound 3l, as effective HDAC8-selective inhibitors with significant anticancer activity against cervical cancer, paving the way for future preclinical and clinical research.
Authors
- Natarajan Kiruthiga (ORCID: https://orcid.org/0000-0002-7230-2003)
- Adhirajan Natarajan
- K. Sureshkumar
- Stalin Arulsamy (ORCID: https://orcid.org/0009-0005-5502-1831)
- Sunil Kumar Bandral
- Venkatesh gunasekar
- Vaishnavi Vallinayagam
Institutions
- Tamil Nadu Dr. M.G.R. Medical University (IN)
- M S Ramaiah University of Applied Sciences (IN)
Publication Details
- Journal
- Medicinal Chemistry
- Published
- 2026-03-02
- DOI
- https://doi.org/10.2174/0115734064378681251128061500
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00