Engineered Bacteria That Eat Tumors: Quorum-Sensing Clostridium sporogenes as a Programmable Cancer Therapy Platform

A bilingual (English/Russian) science communication article exploring how engineered Clostridium sporogenes bacteria can be programmed to selectively destroy solid tumors using quorum-sensing genetic circuits. The article covers the synthetic biology breakthrough published in ACS Synthetic Biology (DOI: 10.1021/acssynbio.5c00628), including the molecular mechanism, clinical implications, and critical analysis of the research. Published on Sigmatic (https://sigmatic.science/en/bacteria-cancer-clostridium-therapy/).

Authors

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-03-02
DOI
https://doi.org/10.5281/zenodo.18888639
Primary Topic
Cancer Research and Treatments
Type
article
Field-Weighted Citation Impact
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article

Engineered Bacteria That Eat Tumors: Quorum-Sensing Clostridium sporogenes as a Programmable Cancer Therapy Platform

Vitaliy Kanev
Zenodo (CERN European Organization for Nuclear Research)
Cancer Research and Treatments
article

Engineered Bacteria That Eat Tumors: Quorum-Sensing Clostridium sporogenes as a Programmable Cancer Therapy Platform

Vitaliy Kanev
article en

Abstract

A bilingual (English/Russian) science communication article exploring how engineered Clostridium sporogenes bacteria can be programmed to selectively destroy solid tumors using quorum-sensing genetic circuits. The article covers the synthetic biology breakthrough published in ACS Synthetic Biology (DOI: 10.1021/acssynbio.5c00628), including the molecular mechanism, clinical implications, and critical analysis of the research. Published on Sigmatic (https://sigmatic.science/en/bacteria-cancer-clostridium-therapy/).

Zenodo (CERN European Organization for Nuclear Research)
Quality Education
Openalex Percentile: Top 35%
Cancer Research and Treatments
DOIOpen Access PDFOpenAlex
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Engineered Bacteria That Eat Tumors: Quorum-Sensing Clostridium sporogenes as a Programmable Cancer Therapy Platform — Vitaliy Kanev · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS