FAM188B promotes progression of hepatocellular carcinoma by regulating YAP/TAZ via interaction with USP10
Our findings reveal that FAM188B plays a crucial role in enhancing HCC cell proliferation, migration, and invasion, primarily through regulating the USP10/YAP/TAZ signaling axis, which was validated <i>in vitro</i> and <i>in vivo</i>.
Authors
- Yuliang Fang (ORCID: https://orcid.org/0000-0001-7693-6225)
- Shen Hu (ORCID: https://orcid.org/0000-0001-9488-0376)
- Lili Tu
- Yihong Chen (ORCID: https://orcid.org/0000-0001-7364-8180)
- Qiuran Xu
- Kangsheng Tu (ORCID: https://orcid.org/0000-0002-0032-1459)
- Mingshan Mu
- Xin Liu
- Yuting Wen
- Wenhu Chen
- Xiaoyan Li
- Dongsheng Huang
Institutions
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Journal of Cancer
- Published
- 2026-03-04
- DOI
- https://doi.org/10.7150/jca.125659
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Education of Zhejiang Province
- Fundamental Research Funds for the Central Universities
- Science and Technology Department of Zhejiang Province
- Natural Science Foundation of Zhejiang Province