Bimetallic Cu/Fe-MOF-based heterojunction sonozymes for triple amplification of sono-immunotherapy through activating tumor-specific cuproptosis and cGAS-STING pathway

The combination therapy of CDT, SDT, cuproptosis, and cGAS-STING activation via FCMM, achieved complete elimination of primary tumor and significant controlled the growth of distant tumor. This work combines sonocatalytic nanomedicine with immune modulation strategy through integrating ROS amplification, cGAS-STING activation, and cuproptosis effect into a single nanoplatform, providing new insights for the clinical application of sono-immunotherapy.