The emerging endogenous peptide Apelin 13 in diabetes and its related complications: a narrative review
Apelin-13 decreases oxidative stress and inflammation through the SIRT1/PGC-1α axis, protects against cardiac remodeling by inhibiting TGF-β/Smad and NF-κB pathways, and prevents renal fibrosis through AMPK-mediated autophagy. Regulating VEGF and TNF-α signaling helps reduce vascular leakage and neuroinflammation.
Authors
- Uma Jyoti
- Takveer Singh (ORCID: https://orcid.org/0000-0003-2979-1590)
- Saurav Singla
Institutions
- Chitkara University (IN)
Publication Details
- Journal
- Expert Opinion on Therapeutic Targets
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1080/14728222.2026.2638751
- Primary Topic
- Apelin-related biomedical research
- Type
- article
- Field-Weighted Citation Impact
- 0.00