Kisspeptin Restores Placental <scp>mTOR</scp> Signaling and Improves Glucose Homeostasis Mediators Disrupted by Maternal Hypothyroidism in Rats
These findings suggest that kisspeptin-10 treatment in hypothyroid pregnant rats improves placental mTOR signaling and glucose metabolism mediators, highlighting novel pathways through which kisspeptin may modulate placental physiology.
Authors
- Bianca Reis Santos (ORCID: https://orcid.org/0000-0001-7587-6662)
- Rogéria Serákides (ORCID: https://orcid.org/0000-0001-5374-6242)
- Luciano Cardoso Santos (ORCID: https://orcid.org/0000-0001-7679-1353)
- Jeane Martinha dos Anjos Cordeiro (ORCID: https://orcid.org/0000-0002-7209-6043)
- Cleisla Souza Oliveira (ORCID: https://orcid.org/0009-0008-9588-4027)
- Natália Panhoca Rodrigues
- Amanda Nancy Sferruzzi-Perri
- Juneo Freitas Silva
- Jorge Lopez-Tello
- Maria Clara Pascoal Santos Alvarez
Institutions
- Universidade Federal de Minas Gerais (BR)
- University of Cambridge (GB)
- Universidade Estadual de Santa Cruz (BR)
- Fundação de Estudo e Pesquisa em Medicina Veterinária e Zootecnia (BR)
- Universidad Autónoma de Madrid (ES)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1111/apha.70188
- Primary Topic
- Hypothalamic control of reproductive hormones
- Type
- article
- Field-Weighted Citation Impact
- 0.00