Distinct Proteomic Signatures Driving Progression of Sarcopenia: A Longitudinal Multicohort Study
This study identified and validated plasma protein signatures and pathways associated with sarcopenia progression. Complement activation, acute inflammatory response and lipid dysregulation emerged as central mechanisms. These robustly validated biomarkers may represent targets for early detection and intervention strategies in sarcopenia.
Authors
- Seung Shin Park (ORCID: https://orcid.org/0000-0001-5719-1539)
- DoHyun Han
- Ok Hee Jeon
- Hak Chul Chang
- Ji Yeon Kim (ORCID: https://orcid.org/0000-0001-9123-3675)
- Sung Hye Kong
- Jinhee Kim
- Miji Kim
- Chang Won Won
Institutions
- Seoul National University (KR)
- Korea University (KR)
- Seoul National University Hospital (KR)
- Seoul National University Bundang Hospital (KR)
- Kyung Hee University (KR)
- Kyung Hee University Medical Center (KR)
- Ajou University (KR)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1002/jcsm.70240
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00