Plasma exchange aids thyroidectomy in refractory amiodarone-induced thyrotoxicosis, despite variable biochemical responses
TPE may provide temporary biochemical improvement and clinical stabilisation in refractory AIT, facilitating safe progression to thyroidectomy. However, its biochemical effects can be inconsistent and transient, and complications such as coagulopathy must be anticipated. Our experience supports the use of TPE as a valuable adjunct in selected patients with refractory AIT but illustrates that thyroidectomy should not be unnecessarily delayed in pursuit of complete TH normalisation or rigid biochemical targets.
Authors
- Mark Sherlock (ORCID: https://orcid.org/0000-0003-4078-624X)
- Amy Hudson
- Susan Elizabeth McKenna
- Jonathan Lyne (ORCID: https://orcid.org/0000-0002-0257-8629)
- Vanessa Farnan
- Sarah Jean Lawless (ORCID: https://orcid.org/0000-0002-8210-3024)
- David Halsall (ORCID: https://orcid.org/0000-0002-2301-6449)
- Robert C. McEvoy
- David J Tansey
- Michael O’Reilly (ORCID: https://orcid.org/0000-0002-9108-9105)
- Rory McQuillan
- Margaret Griffin
- Neville Shine
- Carol Traynor
- Amar Agha
- James Paul O’Neill
- Steven Frohlich
- Carla Moran
- Michelle Maher
- Colm Magee
Institutions
- University College Dublin (IE)
- Royal College of Surgeons in Ireland (IE)
- Beacon College (US)
- Beaumont Hospital (IE)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- St. Vincent's University Hospital (IE)
- Community Partners (US)
Publication Details
- Journal
- European Thyroid Journal
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1530/etj-25-0351
- Primary Topic
- Thyroid and Parathyroid Surgery
- Type
- article
- Field-Weighted Citation Impact
- 0.00