Characterizing the heterogeneity of heart failure with preserved ejection fraction: moving beyond subgroups and distinguishing disease from risk
HFpEF risk and disease course reflect a variable interplay of pathophysiological processes in each individual. This study provides a biologically plausible framework to guide a more personalised approach to HFpEF.
Authors
- Simon G. Williams (ORCID: https://orcid.org/0000-0001-7396-4108)
- Maria F. Paton (ORCID: https://orcid.org/0000-0001-8517-4621)
- Gaetano Nucifora (ORCID: https://orcid.org/0000-0003-2890-440X)
- Naing Ko Ko
- Sarah Kreppel
- Matthias Schmitt (ORCID: https://orcid.org/0000-0001-8514-0261)
- Janine Beezer (ORCID: https://orcid.org/0000-0001-7135-5886)
- Fardad Soltani (ORCID: https://orcid.org/0000-0003-2030-9761)
- Andrew P. Morris (ORCID: https://orcid.org/0000-0002-6805-6014)
- David A. Jenkins
- Joshua Bradley
- Nicholas Black
- Rebecca Hyland
- Nick Hartshorne-Evans
- Shaun Robinson
- William G Newman
- J Mayet
- Lucy Priestner
- Isabelle Milner
- Christopher A Miller
- Hannah Glasse
- Abdallah Al-Mohammad
- Mark C Petrie
- Laurence Humphreys-Davies
- R Thomas Lumbers
- Gerry P McCann
- Zahra Raisi-Estabragh
- Steffen E Petersen
- Theresa McDonagh
Institutions
- Lancashire Teaching Hospitals NHS Foundation Trust (GB)
- St Bartholomew's Hospital (GB)
- University of Leeds (GB)
- University College London Hospitals NHS Foundation Trust (GB)
- Imperial College Healthcare NHS Trust (GB)
- Barts Health NHS Trust (GB)
- University of Cambridge (GB)
- Leeds Teaching Hospitals NHS Trust (GB)
- Manchester Academic Health Science Centre (GB)
- Salford Royal NHS Foundation Trust (GB)
- Wrightington, Wigan and Leigh NHS Foundation Trust (GB)
- University of Manchester (GB)
- Manchester University NHS Foundation Trust (GB)
- Evolutionary Genomics (United States) (US)
- King's College Hospital NHS Foundation Trust (GB)
- Arthritis UK (GB)
- Sunderland Royal Hospital (GB)
- British Society for Rheumatology (GB)
- South Tyneside and Sunderland NHS Foundation Trust (GB)
- Health Data Research UK (GB)
- Civil Service (GB)
- Farr Institute (GB)
- William Harvey Research Institute (GB)
- NIHR Manchester Biomedical Research Centre (GB)
- NIHR Leicester Biomedical Research Centre (GB)
- University College London (GB)
- Marvell (Israel) (IL)
- University of Glasgow (GB)
- University of Sheffield (GB)
Publication Details
- Journal
- European Journal of Heart Failure
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1093/ejhf/xuag056
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00