Thermal ablation versus hepatectomy for solitary colorectal liver metastases up to 5 cm: a multicenter target trial emulation on safety, efficacy, and cost-effectiveness

For SCLM ≤ 5 cm, TA provides comparable oncologic outcomes to HT, alongside superior safety and cost-effectiveness. This supports its role as a first-line therapeutic alternative for selected patients or when surgery is contraindicated.

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Publication Details

Journal
BMC Medicine
Published
2026-03-05
DOI
https://doi.org/10.1186/s12916-026-04767-2
Primary Topic
Hepatocellular Carcinoma Treatment and Prognosis
Type
article
Field-Weighted Citation Impact
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article

Thermal ablation versus hepatectomy for solitary colorectal liver metastases up to 5 cm: a multicenter target trial emulation on safety, efficacy, and cost-effectiveness

MD Xiaohui Ji, Xinyan Huang, Jianming Li, Lei Li et al.
BMC Medicine
Hepatocellular Carcinoma Treatment and Prognosis
article

Thermal ablation versus hepatectomy for solitary colorectal liver metastases up to 5 cm: a multicenter target trial emulation on safety, efficacy, and cost-effectiveness

MD Xiaohui Ji, Xinyan Huang, Jianming Li, Lei Li, Lu Li, Haibo Shao, Huage Zhong, Zhishuai Li, Yongyan Gao, Kexin Lou, G J He, Jie Yu, De-zhi Zhang, Hong Yang, Ping Liang, Erjiao Xu, Huarong Li, Yu Song, Kai Li, Man Lu, Guangjian Liu, Bin Ren, Qian Li
article en

Abstract

For SCLM ≤ 5 cm, TA provides comparable oncologic outcomes to HT, alongside superior safety and cost-effectiveness. This supports its role as a first-line therapeutic alternative for selected patients or when surgery is contraindicated.

BMC Medicine
Hebei Medical University (CN), Sun Yat-sen University (CN), Guangxi Medical University (CN), Second Military Medical University (CN), Dalian Medical University (CN), Jilin University (CN), Anhui Medical University (CN), Chinese PLA General Hospital (CN), Qinghai University Affiliated Hospital (CN), Sixth Affiliated Hospital of Sun Yat-sen University (CN), Second Affiliated Hospital of Dalian Medical University (CN), Fourth Hospital of Hebei Medical University (CN), Aerospace Center Hospital (CN), Sichuan Cancer Hospital (CN), First Hospital of Jilin University (CN), First Affiliated Hospital of GuangXi Medical University (CN), The First Affiliated Hospital, Sun Yat-sen University (CN), First Teaching Hospital of Tianjin University of Traditional Chinese Medicine (CN), Xuzhou Central Hospital (CN), Eastern Hepatobiliary Surgery Hospital (CN), First Hospital of China Medical University (CN), Henan Cancer Hospital (CN), Third Affiliated Hospital of Sun Yat-sen University (CN), Second Affiliated Hospital of Anhui Medical University (CN), Xijing Hospital (CN), Beijing Haidian Hospital (CN), Eighth Affiliated Hospital of Sun Yat-sen University, China Medical University (CN), Air Force Medical University (CN)
Good health and well-being
Openalex Percentile: Top 36%
Hepatocellular Carcinoma Treatment and Prognosis
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