Identification of key macrophage-related genes in systemic sclerosis–associated interstitial lung disease based on single-cell and bulk transcriptomic data

The findings of this study highlight the key roles of ARG2, ELF3, and NKX2-1 in macrophage-related mechanisms of SSc-ILD, providing insights into potential therapeutic targets. Further research is necessary to explore their functional implications in disease progression and treatment.

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Publication Details

Journal
PLoS ONE
Published
2026-03-05
DOI
https://doi.org/10.1371/journal.pone.0344166
Primary Topic
Systemic Sclerosis and Related Diseases
Type
article
Field-Weighted Citation Impact
0.00

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article

Identification of key macrophage-related genes in systemic sclerosis–associated interstitial lung disease based on single-cell and bulk transcriptomic data

Ting Zhao, Yulin Wang, Fu-an Lin
PLoS ONE
Systemic Sclerosis and Related Diseases
article

Identification of key macrophage-related genes in systemic sclerosis–associated interstitial lung disease based on single-cell and bulk transcriptomic data

Ting Zhao, Yulin Wang, Fu-an Lin
article en

Abstract

The findings of this study highlight the key roles of ARG2, ELF3, and NKX2-1 in macrophage-related mechanisms of SSc-ILD, providing insights into potential therapeutic targets. Further research is necessary to explore their functional implications in disease progression and treatment.

PLoS ONEVol. 21(3)
Fujian Medical University (CN), Zhangzhou Municipal Hospital of Fujian Province (CN)
Fujian Medical University
Good health and well-being
Openalex Percentile: Top 33%
Systemic Sclerosis and Related Diseases
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