Identification of key macrophage-related genes in systemic sclerosis–associated interstitial lung disease based on single-cell and bulk transcriptomic data
The findings of this study highlight the key roles of ARG2, ELF3, and NKX2-1 in macrophage-related mechanisms of SSc-ILD, providing insights into potential therapeutic targets. Further research is necessary to explore their functional implications in disease progression and treatment.
Authors
- Ting Zhao
- Yulin Wang
- Fu-an Lin
Institutions
- Fujian Medical University (CN)
- Zhangzhou Municipal Hospital of Fujian Province (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-03-05
- DOI
- https://doi.org/10.1371/journal.pone.0344166
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fujian Medical University