Development of a prognostic model for sepsis based on gut microbiota-associated genes and identification of potential targets
The GMGscore is a robust prognostic tool for sepsis. RORA, targeted by gut microbiota metabolites, may regulate immune balance via effector T cells and NK cells. These findings advance understanding of gut microbiota-sepsis crosstalk and provide new avenues for precise prognosis and targeted therapy.
Authors
- Wei Zhang (ORCID: https://orcid.org/0000-0001-5292-7308)
- Han Xiao (ORCID: https://orcid.org/0000-0003-1978-9593)
- Minrong Xu
- Fangqiong Li (ORCID: https://orcid.org/0009-0005-2092-5099)
- Ping Hu
Institutions
- Zhejiang Chinese Medical University (CN)
- Tongde Hospital of Zhejiang Province (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-03-05
- DOI
- https://doi.org/10.3389/fmed.2026.1766359
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Zhejiang Traditional Chinese Medicine Administration