Differential quadruple pattern: A new EEG signal classification framework

EEG signals are the letters of the brain and reflect neural activity.Abnormal EEG patterns indicate brain disorders such as epilepsy.Recently, machine learning has enabled automated EEG interpretation with high accuracy.This study introduces an explainable EEG classification model based on feature engineering.A novel feature extractor, Differential Quadruple Pattern (DiffQuadPat), is proposed.DiffQuadPat computes relations between four channel values using difference-based transformations and combinational transition tables.Feature selection is performed by Cumulative Weight Neighborhood Component Analysis (CWNCA), and classification is achieved with t-algorithm-based k-Nearest Neighbors (tkNN).For interpretability, Directed Lobish (DLOB) is used to produce symbolic explanations.The proposed DiffQuadPatcentric XFE framework was validated on two EEG datasets: Amyotrophic Lateral Sclerosis (ALS) and neonatal epilepsy detection.The model achieved over 98% accuracy under 10-fold crossvalidation.Furthermore, cortical and hemispheric connectome diagrams were generated, enabling transparent visualization of brain-level interactions.

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Publication Details

Journal
IBRO Neuroscience Reports
Published
2026-03-05
DOI
https://doi.org/10.1016/j.ibneur.2026.03.002
Primary Topic
EEG and Brain-Computer Interfaces
Type
article
Field-Weighted Citation Impact
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article

Differential quadruple pattern: A new EEG signal classification framework

Bilge Özgör, Mehmet Bayğın, Ömer Faruk Göktaş, Turker Tuncer et al.
IBRO Neuroscience Reports
EEG and Brain-Computer Interfaces
article

Differential quadruple pattern: A new EEG signal classification framework

Bilge Özgör, Mehmet Bayğın, Ömer Faruk Göktaş, Turker Tuncer, Sengul Dogan
article en

Abstract

EEG signals are the letters of the brain and reflect neural activity.Abnormal EEG patterns indicate brain disorders such as epilepsy.Recently, machine learning has enabled automated EEG interpretation with high accuracy.This study introduces an explainable EEG classification model based on feature engineering.A novel feature extractor, Differential Quadruple Pattern (DiffQuadPat), is proposed.DiffQuadPat computes relations between four channel values using difference-based transformations and combinational transition tables.Feature selection is performed by Cumulative Weight Neighborhood Component Analysis (CWNCA), and classification is achieved with t-algorithm-based k-Nearest Neighbors (tkNN).For interpretability, Directed Lobish (DLOB) is used to produce symbolic explanations.The proposed DiffQuadPatcentric XFE framework was validated on two EEG datasets: Amyotrophic Lateral Sclerosis (ALS) and neonatal epilepsy detection.The model achieved over 98% accuracy under 10-fold crossvalidation.Furthermore, cortical and hemispheric connectome diagrams were generated, enabling transparent visualization of brain-level interactions.

IBRO Neuroscience ReportsVol. 20
Fırat University (TR), Inonu University (TR), Erzurum Technical University (TR), Ankara Yıldırım Beyazıt University (TR)
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EEG and Brain-Computer Interfaces
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