Expression of immune-related genes and possible regulatory mechanisms in ulcerative colitis

Our findings suggest that HNF4A may be associated with T cell activation and potential regulation of CD28 in UC. Importantly, we improved our understanding of the immune landscape in UC inflammatory tissue using scRNA-seq and bulk sequencing data.

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Publication Details

Journal
Frontiers in Molecular Biosciences
Published
2026-03-05
DOI
https://doi.org/10.3389/fmolb.2026.1621643
Primary Topic
Single-cell and spatial transcriptomics
Type
article
Field-Weighted Citation Impact
0.00
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article

Expression of immune-related genes and possible regulatory mechanisms in ulcerative colitis

Fanfan Qu, Jiaxin Li, AiHua Shen, Baoqing Xu et al.
Frontiers in Molecular Biosciences
Single-cell and spatial transcriptomics
article

Expression of immune-related genes and possible regulatory mechanisms in ulcerative colitis

Fanfan Qu, Jiaxin Li, AiHua Shen, Baoqing Xu, Yang He, Jiayin Li, Yi Zhou, Yanda Wang
article en

Abstract

Our findings suggest that HNF4A may be associated with T cell activation and potential regulation of CD28 in UC. Importantly, we improved our understanding of the immune landscape in UC inflammatory tissue using scRNA-seq and bulk sequencing data.

Frontiers in Molecular BiosciencesVol. 13
Tianjin University of Traditional Chinese Medicine (CN), Yanbian University (CN), First Teaching Hospital of Tianjin University of Traditional Chinese Medicine (CN)
Partnerships for the goals
Openalex Percentile: Top 32%
Single-cell and spatial transcriptomics
DOIOpen Access PDFOpenAlex
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