A Case of Lepromatous Leprosy: Role of Additional Special Stains in Diagnosis

Lepromatous leprosy, more commonly seen in endemic areas, is a severe multi-bacillary granulomatous infection of the skin and peripheral nerves, which leads to facial disfigurement and digital auto-amputation. Although treatable with multidrug therapy, diagnosis and early intervention remains of paramount importance. The bacilli are strongly positive with Fite special stain, and to this day this stain remains most widely used especially in areas that do not have access to PCR testing. Herein, we describe a case where the M. leprae bacilli were Fite positive but also very strongly GMS positive. This case highlights the value of using multiple special stains in diagnosis of leprosy.

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Publication Details

Journal
American Journal of Dermatopathology
Published
2026-03-05
DOI
https://doi.org/10.1097/dad.0000000000003257
Primary Topic
Leprosy Research and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

A Case of Lepromatous Leprosy: Role of Additional Special Stains in Diagnosis

Jonwei Hwang, Silvija P. Gottesman, Bria Midgette
American Journal of Dermatopathology
Leprosy Research and Treatment
article

A Case of Lepromatous Leprosy: Role of Additional Special Stains in Diagnosis

Jonwei Hwang, Silvija P. Gottesman, Bria Midgette
article en

Abstract

Lepromatous leprosy, more commonly seen in endemic areas, is a severe multi-bacillary granulomatous infection of the skin and peripheral nerves, which leads to facial disfigurement and digital auto-amputation. Although treatable with multidrug therapy, diagnosis and early intervention remains of paramount importance. The bacilli are strongly positive with Fite special stain, and to this day this stain remains most widely used especially in areas that do not have access to PCR testing. Herein, we describe a case where the M. leprae bacilli were Fite positive but also very strongly GMS positive. This case highlights the value of using multiple special stains in diagnosis of leprosy.

American Journal of Dermatopathology
Northwell Health (US), Donald & Barbara Zucker School of Medicine at Hofstra/Northwell (US), North Shore Diabetes and Endocrine Associates (US)
Openalex Percentile: Top 34%
Leprosy Research and Treatment
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