Detection of spike protein in term placentas of COVID-19 vaccinated and/or SARS-CoV-2 infected women

The spike protein of SARS-CoV-2 has been be detected in placental Hofbauer and Trophoblast cells as well as villous endothelia after infection and vaccination indicating a possible transplacental transfer or uptake. These findings may suggest a potential for transplacental transfer or cellular uptake; however, the extent, mechanisms, and clinical significance of this phenomenon remain to be fully understood. Clinical trial registration: DRKS00022506.

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Publication Details

Journal
PLoS ONE
Published
2026-03-05
DOI
https://doi.org/10.1371/journal.pone.0344185
Primary Topic
COVID-19 Impact on Reproduction
Type
article
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article

Detection of spike protein in term placentas of COVID-19 vaccinated and/or SARS-CoV-2 infected women

M Mörz, Catharina Bartmann, Achim Wöckel, PhD Vanessa Schmidt et al.
PLoS ONE
COVID-19 Impact on Reproduction
article

Detection of spike protein in term placentas of COVID-19 vaccinated and/or SARS-CoV-2 infected women

M Mörz, Catharina Bartmann, Achim Wöckel, PhD Vanessa Schmidt, Michael Schwab, Monika Rehn, Bettina Blau-Schneider, Ulrike Kämmerer
article en

Abstract

The spike protein of SARS-CoV-2 has been be detected in placental Hofbauer and Trophoblast cells as well as villous endothelia after infection and vaccination indicating a possible transplacental transfer or uptake. These findings may suggest a potential for transplacental transfer or cellular uptake; however, the extent, mechanisms, and clinical significance of this phenomenon remain to be fully understood. Clinical trial registration: DRKS00022506.

PLoS ONEVol. 21(3)
Städtisches Klinikum Dresden (DE), St. Josefs Hospital (DE), Krankenhaus Dresden-Friedrichstadt (DE), Universitätsklinikum Würzburg (DE), CS Diagnostics (DE)
Good health and well-being
Openalex Percentile: Top 31%
COVID-19 Impact on Reproduction
DOIOpen Access PDFOpenAlex
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