Protein Kinase R-like Endoplasmic Reticulum Kinase-Mediated ER-Mitochondria Coupling Regulates Odontogenic Differentiation of Human Dental Pulp Stem Cells Under Inflammatory Stimuli
This study demonstrates that LPS-induced inflammatory stress reprograms hDPSCs bioactivity via PERK-centric control of MAMs likely through quantitative enhancement, structure specialization, and functional potentiation. The underlying mechanisms may involve IP3R-mediated regulation of calcium ion influx and protein interactions within MAMs.
Authors
- Yi Jin (ORCID: https://orcid.org/0000-0003-1794-7017)
- Yiqing Wang (ORCID: https://orcid.org/0000-0002-8386-5653)
- Ruirui Liu
- Zhipu Luo
- Yiqiao Li
Institutions
- Second Military Medical University (CN)
- Shanghai Pudong New Area Gongli Hospital (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- International Dental Journal
- Published
- 2026-03-05
- DOI
- https://doi.org/10.1016/j.identj.2026.109440
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00