Neuropsychiatric Symptoms in Patients With Pathologically Confirmed Comorbid Alzheimer Disease and Frontotemporal Lobar Degeneration
Comorbid presence of ADNC and FTLD neuropathology, compared with each pathology alone, was associated with a greater likelihood of presenting with known neuropsychiatric symptoms of the other disease, irrespective of patients' clinical syndrome. Findings highlight the potential clinical diagnostic value of antemortem behavioral symptoms in identifying patients with comorbid pathology, although conclusions are limited by the cross-sectional nature of the neuropsychiatric data.
Authors
- Molly Split
- Daliah Ross (ORCID: https://orcid.org/0000-0002-0577-7578)
- Zachary J. Kunicki (ORCID: https://orcid.org/0000-0002-3466-7589)
- Rachel Keszycki (ORCID: https://orcid.org/0000-0001-7686-2959)
- Sarah Prieto (ORCID: https://orcid.org/0000-0001-5697-3010)
- Masood Manoochehri (ORCID: https://orcid.org/0000-0001-5818-180X)
- Alyssa N. De Vito (ORCID: https://orcid.org/0000-0002-4078-3869)
- Edward D Huey
- Megan S. Barker
Institutions
- Northwestern University (US)
- Providence College (US)
- Brown University (US)
- Butler Hospital (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
Publication Details
- Journal
- Neurology
- Published
- 2026-03-05
- DOI
- https://doi.org/10.1212/wnl.0000000000214750
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 33.12