Gastrin ameliorates heart failure and suppresses myocardial remodeling via the JAK2/STAT3 and ERK1/2 pathways

Gastrin may exert protective effects against ISO-induced HF and myocardial remodeling by inhibiting the JAK2/STAT3 and ERK1/2 pathways via the CCK2 receptor.

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Publication Details

Journal
PLoS ONE
Published
2026-03-05
DOI
https://doi.org/10.1371/journal.pone.0343403
Primary Topic
Cardiac Fibrosis and Remodeling
Type
article
Field-Weighted Citation Impact
0.00
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article

Gastrin ameliorates heart failure and suppresses myocardial remodeling via the JAK2/STAT3 and ERK1/2 pathways

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PLoS ONE
Cardiac Fibrosis and Remodeling
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Gastrin ameliorates heart failure and suppresses myocardial remodeling via the JAK2/STAT3 and ERK1/2 pathways

Yalu Du, Jinjing Yang, Haozhou Zhang, Liang Liu, Ning Wang (108353), Xiaohong Chai, Jin Dong, Bao Li
article en

Abstract

Gastrin may exert protective effects against ISO-induced HF and myocardial remodeling by inhibiting the JAK2/STAT3 and ERK1/2 pathways via the CCK2 receptor.

PLoS ONEVol. 21(3)
Shanxi Medical University (CN), Second Hospital of Shanxi Medical University (CN), Shanxi Cardiovascular Hospital (CN)
Good health and well-being
Openalex Percentile: Top 39%
Cardiac Fibrosis and Remodeling
DOIOpen Access PDFOpenAlex
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