Building CRESCENDO – a global registry of glomerulonephritis with crescents

Abstract Crescents represent a non-specific mechanism in response to severe glomerular injury and show a temporal pattern evolving from cellular and fibrocellular to fibrous. Crescentic glomerulonephritis (GN) is defined as ≥50% cellular crescentic glomeruli on kidney histology and is frequently characterized by rapid deterioration of kidney function and features of nephritis. However, little is known on how different types and proportions of crescents affect prognosis and this may differ across diseases forming the spectrum of crescentic GN. To explore this we have devised CRESCENDO, a multinational, longitudinal, observational registry collecting clinical, laboratory and histopathology data from patients with GN and crescents. The registry aims to enroll patients from all continents to explore the prognostic value of crescents on a continuum, ranging from one crescentic glomerulus to 100% crescents on biopsy. We also aim to explore other potential prognostic and diagnostic predictors of a wide range of outcomes (not limited to mortality and kidney survival, but also infections, malignancy, and kidney function recovery), leverage exploratory machine learning approaches of scanned kidney biopsies and test the efficacy and safety of different therapies across crescentic GN spectrum. The findings of CRESCENDO will hopefully help close gaps in the understanding of crescentic GN and will generate further hypotheses providing the basis for subsequent research.

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Publication Details

Journal
Clinical Kidney Journal
Published
2026-03-05
DOI
https://doi.org/10.1093/ckj/sfag077
Primary Topic
Renal Diseases and Glomerulopathies
Type
article
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article

Building CRESCENDO – a global registry of glomerulonephritis with crescents

Matheus Vieira Gonçalves, Anand Chellappan, Adam Morris, Karl Emil Nelveg-Kristensen et al.
Clinical Kidney Journal
Renal Diseases and Glomerulopathies
article

Building CRESCENDO – a global registry of glomerulonephritis with crescents

Matheus Vieira Gonçalves, Anand Chellappan, Adam Morris, Karl Emil Nelveg-Kristensen, Peter Böör, Emma Salvador Pardo, Muzamil Hassan, Benoît Brilland, Bolanle A. Omotoso, Dana Pramudya, Decsa Medika Hertanto, Faten Aqeel, Erik A.M. Verschuuren, Bernardo Marques da Silva, Marc L. Hilhorst, Vincenzo L’Imperio, Tamer Shehab, Sigrid Gertrud Gisela Lundberg, Pablo Javier Cannata Ortíz, Gordana Cavrić, Mazdak Sanaei Nurmi, Lauren Floyd, Ikechi G. Okpechi, Katharina Rohner, Masao Kikuchi, Dino Kasumović, Iolanda Godinho, Bojana Maksimović, Petar Šenjug, Lisa Uchida, Daiki Nakagomi, Tiffany Caza, Aglaia Chalkia, Chen Au Peh, Marek Kollár, Björn Runesson, Claudia Seikrit, Emelie Westergren, Besa Osmani, Duvura Geetha, Rosenberg Avi Z., Michael Fischereder, Thomas Knoop, Raquel Chorão, Mario Laganović, Şafak Mirioğlu, Sofia Homem Melo Marques, Aleksandra Rymarz, Raúl Fernández Prado, Martina Tedesco, Eleni Frangou, Urmila Anandh, Anke von Bergwelt-Baildon, Sofia Correia, Hitomi Miyata, Harald Seeger, Balázs Odler, Samira Bell, Wesam Ismail, Aso Saeed, Andreas Jönsson, Vojtěch Krátký, Fatiu A. Arogundade, Toshiyuki Komiya, Estela Nogueira, Tamara Knežević, J.J. Boffa, Luis Mendonça, George Vasquez-Rios, Patricia Batkovic, Boyer Olivia, Gisele Vajgel, Fernando Caravaca-Fontán, Louise Oni, Edouard L Fu, Rose Muhindo, David Buob, Emmanuel Esteve, Valerie A Luyckx, Anna Julie Peired, Bhadran Bose, Miha Arnol, Toshiko Ito-Ihara, Nikola Zagorec, Ivan Bubić, Krešimir Galešić, Maria K Svensson, Marta Pereira, Vladimir Tesar, Savaş Öztürk, Jan-Stephan Sanders, Alberto Ortiz, Daniel P Gale, Loreto Gesualdo, Lucia Cordero Garcia Galan, Ritambhra Nada, Sofia Santos, Stela Bulimbašić, Jae Il Shin, Haresh Selvaskandan, Joana Gameiro, Shouichi Fujimoto, Samir Parikh, Angela Wang, Brad Rovin, David Saadoun, Salem Almaani, Željka Večerić Haler, Antonio Inacio, Jonathan Barratt, Ajay Dhaygude, Ana Malvar, Dwomoa Adu, Bärbel Lange-Sperandio, Maria A C Wester Trejo, Ingeborg Bajema, Thomas Rauen, Marios Papasotiriou, Ian Roberts, Manish Rathi, Julia Wijkstrom, Jürgen Floege, Arenn Jauhal, Beatriz Sanchez-Alamo, Maria Jose Soler, Sradha Kotwal, David Jayne, Heather Reich, Andreas Kronbichler, João Boavida, Tobias B Huber, Alexandre Karras, Marion Haubitz, Ming-hui Zhao, Michele Maeske, Dimitrios Goumenos, Jose Oliveira, Marten Segelmark, Kate Stevens, CRESCENDO Inves gators, Danica Galešić Ljubanović, Marijana Ćorić, Zdenka Hruskova, Ivica Horvatić, Maria Weiner, Rachel Jones, Nicola M Tomas, Sayna Norouzi, Silke R Brix, Mario Gois, Inga Soveri, Cedric Rafat, Ivo Laranjinha, Ana Gomes, Ulf Schönermarck, Robert Kalyesubula, Annette Bruchfeld, Abdou Niang, Martin Busch, Talerngsak Kanjanabuch, Nika Kojc, Vanja Ivković, Brendon Neuen, Anna Levin, Augusto Vaglio, Stefanie Steiger, Juan M Mejia Vilet, Georgina Maalouf, Raja Ramachandran, Zhao Cui, Angela Maria Cordoba Huerto, Lucy Francis, Nejc Piko, Stephen McAdoo
article en

Abstract

Abstract Crescents represent a non-specific mechanism in response to severe glomerular injury and show a temporal pattern evolving from cellular and fibrocellular to fibrous. Crescentic glomerulonephritis (GN) is defined as ≥50% cellular crescentic glomeruli on kidney histology and is frequently characterized by rapid deterioration of kidney function and features of nephritis. However, little is known on how different types and proportions of crescents affect prognosis and this may differ across diseases forming the spectrum of crescentic GN. To explore this we have devised CRESCENDO, a multinational, longitudinal, observational registry collecting clinical, laboratory and histopathology data from patients with GN and crescents. The registry aims to enroll patients from all continents to explore the prognostic value of crescents on a continuum, ranging from one crescentic glomerulus to 100% crescents on biopsy. We also aim to explore other potential prognostic and diagnostic predictors of a wide range of outcomes (not limited to mortality and kidney survival, but also infections, malignancy, and kidney function recovery), leverage exploratory machine learning approaches of scanned kidney biopsies and test the efficacy and safety of different therapies across crescentic GN spectrum. The findings of CRESCENDO will hopefully help close gaps in the understanding of crescentic GN and will generate further hypotheses providing the basis for subsequent research.

Clinical Kidney Journal
Linköping University (SE), Karolinska University Hospital (SE), Innsbruck Medical University (AT), Karolinska Institutet (SE)
Good health and well-being
Openalex Percentile: Top 41%
Renal Diseases and Glomerulopathies
DOIOpen Access PDFOpenAlex
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