IFNγ-associated immune–metabolic remodeling is linked to serotonin–kynurenine imbalance and cortical vulnerability in lupus-prone mice
Together, these results support an associative framework in which systemic IFNγ levels are linked to cortical metabolic reprogramming and neuronal vulnerability, bridging peripheral immune activation with serotonergic depletion, melatonin loss, axonal injury, and behavioral dysfunction. Translationally, combined blood-based monitoring of IFNγ, NfL, and kynurenine metabolites may represent a candidate biomarker framework for NPSLE. However, validation in independent patient cohorts will be essential, and therapeutic modulation of IDO1/KMO or serotonergic pathways remains an avenue for future investigation.
Authors
- Jean‐Louis Guéant (ORCID: https://orcid.org/0000-0002-5067-042X)
- Karim Matmat (ORCID: https://orcid.org/0009-0009-8226-4846)
- Emmanuel Darcq (ORCID: https://orcid.org/0000-0002-8377-8015)
- Rosa‐Maria Guéant‐Rodriguez (ORCID: https://orcid.org/0000-0003-1402-3716)
- Jean-Marc Alberto
- Okan Baspinar
- Hélène Jeltsch-David
Institutions
- Constructor University (DE)
- Cornell University (US)
- Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie (FR)
- Laboratoire National de Référence (MA)
- Nutrition-Génétique et Exposition aux Risques Environnementaux (FR)
- Université de Strasbourg (FR)
- Université de Lorraine (FR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-05
- DOI
- https://doi.org/10.3389/fimmu.2026.1740039
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00