Platelet mTOR Is a Regulator of Sterile Immunothrombosis
Platelet mTOR is a critical mediator of sterile immunothrombosis, although it is dispensable for hemostasis in mice. The immunothrombotic-specific effects of mTOR make it an attractive therapeutic target with a good safety profile.
Authors
- Abigail Ajanel (ORCID: https://orcid.org/0000-0002-4601-3769)
- Andrew S. Weyrich (ORCID: https://orcid.org/0000-0001-9622-4647)
- Rhonda Souvenir (ORCID: https://orcid.org/0000-0002-8880-2483)
- Irina Portier (ORCID: https://orcid.org/0000-0003-1993-9723)
- Haley Benzon (ORCID: https://orcid.org/0000-0003-4994-1269)
- Cláudia de Araújo
- Frederik Denorme
- E. Dale Abel
- Heide Castro
- Robert A. Campbell
- Yasuhiro Kosaka
- Matthew T. Rondina
Institutions
- University of Antwerp (BE)
- University of California, Los Angeles (US)
- University of Utah (US)
- Oklahoma Medical Research Foundation (US)
- Anna Needs Neuroblastoma Answers (US)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2026-03-05
- DOI
- https://doi.org/10.1161/atvbaha.125.324250
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00