Genetic susceptibility to Alzheimer’s disease and cardiometabolic risk from childhood
While Alzheimer's disease and cardiometabolic diseases may have shared genetic determinants, the associations between genetic susceptibility for Alzheimer's disease and increased cardiometabolic risk from childhood to young adulthood are poorly understood. We investigated the associations of genetic risk score for Alzheimer's disease with cardiometabolic risk from early childhood over a 20-year follow-up. We found that a higher genetic risk score for Alzheimer's disease was associated with higher LDL cholesterol, non-HDL cholesterol, and ApoB, and with lower serum HDL cholesterol and ApoA1. These findings suggest that a genetic predisposition to Alzheimer's disease may alter lipid metabolism from early childhood.
Authors
- Hanna Lagström (ORCID: https://orcid.org/0000-0002-5069-6582)
- Eero A. Haapala (ORCID: https://orcid.org/0000-0001-5096-851X)
- Harri Niinikoski
- Pia Salo
- Jorma SA Viikari
- Juha Mykkänen
- Tapani Rönnemaa
- Suvi Rovio
- Olli T. Raitakari
- Katja Pahkala
- Saara Heinonen
- Antti Jula
Institutions
- University of Turku (FI)
- University of Eastern Finland (FI)
- University of Exeter (GB)
- Turku University Hospital (FI)
- Paavo Nurmen Säätiö (FI)
- University of Jyväskylä (FI)
Publication Details
- Journal
- Pediatric Research
- Published
- 2026-03-05
- DOI
- https://doi.org/10.1038/s41390-026-04860-5
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Foundation for Cardiovascular Research
- Itä-Suomen Yliopisto
- Suomen Lääketieteen Säätiö
- Yrjö Jahnssonin Säätiö
- Suomen Kulttuurirahasto
- Juho Vainion Säätiö
- Kuopion Yliopistollinen Sairaala
- Sydäntutkimussäätiö
- Sigrid Juséliuksen Säätiö
- Turun Yliopistollinen Keskussairaala
- Turun Yliopistosäätiö