ZNF331 Modulates Early Embryonic Transcription During Zygotic Genome Activation in Goat
Our study identifies ZNF331 as a critical regulator of goat ZGA, functioning through fine-tuning Pol II Ser5 phosphorylation to balance maternal transcript clearance and zygotic gene activation. These findings highlight the essential role of the ZNF331-Pol II axis in goat embryogenesis and suggest a potentially conserved mechanism across mammals.
Authors
- J. Y. Zhang
- X. Chen
- Yingnan Yang (ORCID: https://orcid.org/0000-0001-8980-0634)
- Yongjie Wan
- Dongxu Li (ORCID: https://orcid.org/0000-0002-9701-5377)
- Haonan Chen (ORCID: https://orcid.org/0000-0002-9818-2783)
- Mingtian Deng
- Feng Wang
Institutions
- Nanjing Agricultural University (CN)
- Sanya University (CN)
Publication Details
- Journal
- GigaScience
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1093/gigascience/giag025
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 0.00