TP53, HIF1A, and CDKN2A in Hepatocellular Carcinoma: Roles in Senescence, Ferroptosis, and Prognosis

The senescence-ferroptosis-related genes TP53, HIF1A, and CDKN2A demonstrated potential as diagnostic and prognostic biomarkers in HCC. The developed nomogram may support individualized prognostic assessment and inform early diagnostic and therapeutic strategies in patients with HCC.

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Publication Details

Journal
Clinical and Translational Gastroenterology
Published
2026-03-05
DOI
https://doi.org/10.14309/ctg.0000000000001002
Primary Topic
Ferroptosis and cancer prognosis
Type
article
Field-Weighted Citation Impact
0.00
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article

TP53, HIF1A, and CDKN2A in Hepatocellular Carcinoma: Roles in Senescence, Ferroptosis, and Prognosis

Yupeng Wang, Cheng Jiao
Clinical and Translational Gastroenterology
Ferroptosis and cancer prognosis
article

TP53, HIF1A, and CDKN2A in Hepatocellular Carcinoma: Roles in Senescence, Ferroptosis, and Prognosis

Yupeng Wang, Cheng Jiao
article en

Abstract

The senescence-ferroptosis-related genes TP53, HIF1A, and CDKN2A demonstrated potential as diagnostic and prognostic biomarkers in HCC. The developed nomogram may support individualized prognostic assessment and inform early diagnostic and therapeutic strategies in patients with HCC.

Clinical and Translational Gastroenterology
Bethune International Peace Hospital (CN)
Good health and well-being
Openalex Percentile: Top 32%
Ferroptosis and cancer prognosis
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