Clinicopathological and sonographic characterization of NTRK-fusion papillary thyroid carcinoma based on preoperative molecular testing: a comparative study with BRAFV600E PTC
NTRK-fusion defines a distinct PTC molecular subtype characterized by a high burden of LNM and a spectrum of features linked to follicular growth patterns. These findings facilitate the preoperative identification of this tumor subtype and provide a foundation for individualized risk stratification and tailored management strategies.
Authors
- Dehui Zou (ORCID: https://orcid.org/0000-0002-8135-4913)
- Junfang Gai
- Y. Lynn Wang (ORCID: https://orcid.org/0000-0003-0773-1212)
- Xinping Wu (ORCID: https://orcid.org/0000-0002-6330-1615)
- Yuzhi Zhang (ORCID: https://orcid.org/0000-0002-5841-1107)
- Min Han
- Wenbo Ding
- Shuhang Xu
- Xin Wu
- Chao Liu
Institutions
- Nanjing University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-03-05
- DOI
- https://doi.org/10.3389/fonc.2026.1779894
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Government of Jiangsu Province