Cellular signatures of immune dysregulation in inborn errors of immunity: development of a quantitative immune balance score
Our findings identify IDS as a novel quantitative biomarker that captures the regulatory-inflammatory imbalance underlying immune dysregulation, distinguishes PIRDs from non-PIRD IEIs, and provides a translational framework for patient stratification. IDS may inform longitudinal monitoring and guide targeted therapeutic interventions in immune dysregulation syndromes.
Authors
- Melike Ocak (ORCID: https://orcid.org/0000-0001-7841-4690)
- Hacer Neslihan Bildik (ORCID: https://orcid.org/0000-0002-2801-8494)
- Nurten Akarsu (ORCID: https://orcid.org/0000-0001-5432-0032)
- Demir İnan (ORCID: https://orcid.org/0000-0002-8258-9394)
- Deniz Cagdas
- İlhan Tezcan
- Sevil Oskay Halacli
- Busra Ciftcier
- Aslihan Berra Bolat
Institutions
- Institute of Child Health (IN)
- Hacettepe University (TR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-05
- DOI
- https://doi.org/10.3389/fimmu.2026.1735655
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hacettepe Üniversitesi