The clinical, serological and myopathological features of a cohort of Chinese patients with inclusion body myositis: a single center analysis
This cohort of Chinese IBM patients suggested an earlier age at onset than previously reported. Hip flexors were most commonly affected. Female patients showed a higher frequency of dysphagia and neck flexor weakness. Our study reported a high frequency of complement deposition in muscle tissue. Complement deposition was associated with disease severity, suggesting a potential role of complement in the pathophysiology of IBM.
Authors
- Shouzheng Yang
- ZhaoXia Wang
- He Lv (ORCID: https://orcid.org/0000-0002-4148-625X)
- Qiang Gang
- Lingchao Meng
- Meng Yu
- Yinglin Leng (ORCID: https://orcid.org/0009-0002-4579-082X)
- H. Qiu
- Yawen Zhao
- Xuejun Guo
- Yun Yuan
- Jianwen Deng
- Wei Zhang
- Yiming Zheng
Institutions
- Peking University (CN)
- Beijing Jishuitan Hospital (CN)
- Peking University Shenzhen Hospital (CN)
- Peking University First Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-05
- DOI
- https://doi.org/10.3389/fimmu.2026.1782053
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Peking University First Hospital
- National Natural Science Foundation of China
- Peking University