Tissue penetration of anti-tumour necrosis factor therapy in perianal fistulising Crohn’s disease: a proof-of-concept study
Anti-TNF levels in perianal fistula tissue are measurable and correlated with serum concentrations, supporting a mechanistic link between systemic exposure and local drug penetration. These findings highlight the feasibility of tissue-level pharmacokinetic assessments and warrant validation in larger prospective cohorts.
Authors
- J. B. Alexander
- L Hanna (ORCID: https://orcid.org/0009-0004-8424-202X)
- S Anandabaskaran
- Phillip Lung
- Phil Tozer
- Zhigang Liu
- Ailsa Hart
- Susan J. Connor
- Nick Powell
Institutions
- Imperial College Healthcare NHS Trust (GB)
- Liverpool Hospital (AU)
- UNSW Sydney (AU)
- St. Mark's Hospital (US)
- St Mark's Hospital (GB)
- Imperial College London (GB)
Publication Details
- Journal
- European Journal of Gastroenterology & Hepatology
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1097/meg.0000000000003169
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00