A prospective pharmacokinetic study of chlordiazepoxide in patients admitted to an intensive care unit or a high dependency unit after treatment of alcohol withdrawal symptoms
Poor correlation between doses, plasma concentrations, and clinical effects limits the ability to use cumulated doses and plasma concentrations to predict the risk of prolonged sedation and respiratory depression, making chlordiazepoxide unreliable in the treatment of alcohol withdrawal symptoms.
Authors
- Kim Dalhoff (ORCID: https://orcid.org/0000-0002-5548-6381)
- Christian Wamberg
- Theis Skovsgaard Itenov (ORCID: https://orcid.org/0000-0002-1204-3636)
- Charlotte Uggerhøj Andersen (ORCID: https://orcid.org/0000-0003-0543-6519)
- Erikstrup Clausen N
- Tonny Studsgaard Petersen
- Nanna Reiter
- Christian S. Meyhoff
Institutions
- University of Copenhagen (DK)
- Aarhus University (DK)
- Frederiksberg Hospital (DK)
- Aarhus University Hospital (DK)
Publication Details
- Journal
- Clinical Toxicology
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1080/15563650.2026.2630024
- Primary Topic
- Alcoholism and Thiamine Deficiency
- Type
- article
- Field-Weighted Citation Impact
- 0.00