Epigenetic corepressor BCORL1 predominates as a driver of clonal hematopoiesis of indeterminate potential in patients undergoing chronic hemodialysis: a multicenter cohort study

CHIP in Asian patients undergoing chronic hemodialysis shows a high prevalence and a distinct mutation spectrum dominated by BCORL1. These findings suggest disease- and ancestry-specific selective pressures beyond aging and support gene-specific risk stratification and closer hematologic surveillance. Further multi-ethnic studies are needed to define the cardiovascular and hematologic implications of BCORL1-associated CHIP.