Overexpression of ASvicR combined with the antibacterial monomer DMAHDM interferes with the VicRK two-component system to attenuate the cariogenicity of Streptococcus mutans
The strategy of combining AS<i>vicR</i> overexpression with DMAHDM effectively modulates EPS metabolism and cariogenicity in <i>S. mutans</i> by interfering with the VicRK TCS, providing a potential therapeutic approach for clinical caries management.
Authors
- Yu Sun (ORCID: https://orcid.org/0000-0003-0863-2769)
- Ruiqi Yang (ORCID: https://orcid.org/0000-0002-1272-5821)
- Zi Wang (ORCID: https://orcid.org/0000-0002-3953-0493)
- Xinyi Zhang (ORCID: https://orcid.org/0000-0002-3173-0589)
- Han Du (ORCID: https://orcid.org/0000-0001-5516-3032)
- D Q Yang
- Hong Chen
- Xuele Pan
Institutions
- Fudan University (CN)
- Shanghai Stomatological Hospital (CN)
- Stomatological Hospital of Chongqing Medical University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Municipal Health Commission (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-03-05
- DOI
- https://doi.org/10.3389/fcimb.2026.1793140
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00