Age-related adiponectin resistance in human skeletal muscle dysfunction: in vivo and in vitro evidence
These findings highlight a shift in adiponectin signaling during aging, with the downregulation of AdipoR2 promoting systemic adiponectin resistance. Excessive AMPK activity, in the context of impaired AdipoR2 function, contributes to redox imbalance and metabolic dysfunction in the skeletal muscle, favoring a "senescent-like" phenotype.
Authors
- Michelangela Barbieri (ORCID: https://orcid.org/0000-0002-9223-5792)
- Maria Teresa Vietri (ORCID: https://orcid.org/0000-0001-6243-2632)
- Ada Pesapane (ORCID: https://orcid.org/0009-0002-5541-8255)
- Rosaria Anna Fontanella (ORCID: https://orcid.org/0009-0008-5225-3364)
- Surina Surina (ORCID: https://orcid.org/0009-0000-1948-9748)
- Rashmi Joshi (ORCID: https://orcid.org/0000-0001-6065-2594)
- Nunzia Balzano
- Capuano Annalisa
- A. Palazzo
- Lucia Scisciola
- Giuseppe Paolisso
- Zeeshan Ulfat
- Maryam Arshad
- Asad Zia
- Manuela Giovanna Basilicata
Institutions
- University of Campania "Luigi Vanvitelli" (IT)
- Regione Campania (IT)
- Saint Camillus International University of Health and Medical Sciences (IT)
- University of Campania "Luigi Vanvitelli" (IT)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2026-03-05
- DOI
- https://doi.org/10.1186/s12967-026-07959-9
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00