Impact of loading dose β-lactam therapy on outcomes of KPC-producing <i>Klebsiella pneumoniae</i> bloodstream infections in non-ICU patients: a real world study
In non-ICU KPC-Kp BSIs, a β-lactam loading dose regimen was associated with faster microbiological clearance, reduced ICU transfer and shorter hospital stay, without added toxicity. Mortality showed a non-significant trend towards improvement. Pragmatic LD strategies may enhance early β-lactam exposure where therapeutic drug monitoring (TDM) is unavailable. Prospective PK/PD-guided studies are warranted.
Authors
- Fabio Signorile
- Giacomo Guido (ORCID: https://orcid.org/0009-0004-8783-7221)
- Francesco Di Gennaro (ORCID: https://orcid.org/0000-0003-3453-5647)
- Annunziata Ilenia Ritacco
- Antonio De Luca (ORCID: https://orcid.org/0009-0008-3790-3541)
- Giuseppina De Iaco (ORCID: https://orcid.org/0000-0003-4031-8219)
- Cibelli Marinella
- Annalisa Saracino
- Luisa Frallonardo
- Nicolò De Gennaro
- Stefania Stolfa
Institutions
- University of Bari Aldo Moro (IT)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2026-03-02
- DOI
- https://doi.org/10.1093/jac/dkag087
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 21.79